Engineering self-contained DNA circuit for proximity recognition and localized signal amplification of target biomolecules
نویسندگان
چکیده
منابع مشابه
Engineering self-contained DNA circuit for proximity recognition and localized signal amplification of target biomolecules
Biomolecular interactions have important cellular implications, however, a simple method for the sensing of such proximal events is lacking in the current molecular toolbox. We designed a dynamic DNA circuit capable of recognizing targets in close proximity to initiate a pre-programmed signal transduction process resulting in localized signal amplification. The entire circuit was engineered to ...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2014
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gku655